Polyethylene Glycol

Description of Polyethylene Glycol:

Polyethylene glycol is a polyether compound with many applications, from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
PEG has been examined extensively as a drug delivering vehicle because of its solubility in both organic and hydrophilic solvents. In contrast to many other synthetic polymers, PEG is relatively hydrophilic and can be conjugated to other polymers to make them less hydrophobic.

Key Characteristics

  • Hydrophilic: Attracts and retains water.
  • Non-toxic: Generally considered safe for human use.
  • Biocompatible: Compatible with biological systems.
  • Molecular weight variability: Available in different molecular weights, influencing its properties.

Application of Polyethylene Glycol:

Polyethylene Glycol

Polyethylene Glycol is used in a wide range in many industries, such as Medical: Polyethylene Glycol in surgery and colonoscopy, X-Ray diffraction, PEG for Gene Therapy, Blood Banking.

Pharmaceutical

  • Laxative: PEG-based solutions are commonly used to treat constipation.
  • Drug delivery: Used in drug formulation to improve solubility, stability, and bioavailability.
  • Medical devices: Employed in coatings for medical implants and devices.

Cosmetics

  • Emulsifier: Helps to mix oil and water-based ingredients.
  • Humectant: Attracts and retains moisture in the skin.
  • Surfactant: Reduces surface tension, improving the feel and spreadability of products.

Industrial

  • Anti-foaming agent: Reduces foam formation in industrial processes.
  • Lubricant: Used as a lubricant in various applications.
  • Polymer synthesis: Serves as a starting material for other polymers.

Handling Precautions

  • Ventilation: Ensure adequate ventilation when handling PEG, especially in powdered form, to avoid inhalation of dust.
  • Personal Protective Equipment (PPE): Wear appropriate PPE, including gloves, safety goggles, and laboratory coats, to protect skin and eyes from contact.
  • Hygiene: Avoid contact with eyes, skin, and mouth. Wash hands thoroughly after handling PEG.
  • Storage: Store PEG in tightly closed containers in a cool, dry place away from incompatible substances.
    Waste Disposal: Dispose of PEG waste according to local regulations.

Safety Considerations

  • Skin Contact: PEG can cause irritation to the skin. In case of contact, wash the affected area with plenty of water.
  • Eye Contact: PEG can cause irritation to the eyes. In case of contact, rinse eyes thoroughly with water for several minutes and seek medical attention if irritation persists.
  • Inhalation: Inhalation of PEG dust may cause respiratory irritation. If inhaled, move the person to fresh air and seek medical attention if symptoms persist.
  • Ingestion: If swallowed, seek medical attention immediately.

Packing of Polyethylene Glycol:

  • Liquid form: PEG (200 up to 1000) are packed in 180 kg drums , iso tank , flexi tanks and bulk shipments. Each 20 foot container takes 80 drum.
  • Solid form: PEG ( from 1000) packed in Bag ( net : 25 Kg). The PEG products have shelf life of 24 months from the date of manufacture & maintained in adequate storage condition. Shelf life of pharmacy grades is 12 months.

Specification of Polyethylene Glycol

TESTSTANDARDUnitRef
Completeness an d color of Solution:, 5g/50ml of WaterSlightly HazyUSP39-NF34
Viscosity @ 98.9˚C76-110CstUSP39-NF34
pH, 5% Solution in Water4.5-7.5USP39-NF34
Residue on ignitionMax 0.1%wtUSP39-NF34
Assay (Average Molecular Weight)3015-3685g/molUSP39-NF34
Heavy metalsMax 5ppmUSP39-NF34
Ethylene Oxide & 1,4-DioxaneMax. 10
(for each of them)
vUSP39-NF34

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